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KMID : 0385019990150020207
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 2 p.207 ~ p.212
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Development of an Apparatus for Inhalation Anesthesia in Small Laboratory Animals
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박정환/Park, Jung hwan
이민재/한진수/Lee, Min Jae/Han, Jin Soo
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Abstract
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Volatile anesthetics offer several advantages over injectable anesthetics for small animal surgery. Volatile anesthetics and delivery systems are often prohibitively expensive for rodent uses. Therefore, many researchers who carry out small animal experiments use an empty camera film container or a syringe filled with gauze or cotton soaked with diethyl ether. In these conventional open-drop method, the laboratory environment becomes potentially hazardous to vaporization of diethyl ether and it is also very difficult to control the anesthetic depth. Therefore, we developed an inhalation anesthesia apparatus for small laboratory animals. It can be used in conjunction with other volatile anesthetics such as isoflurane, halothane, and enflurane. It has been used in many experiments.
The apparatus consists of an infusion set for dropping the anesthetic, a vaporizing inner-chamber, a vaporizing medium, a multi-punched nose cone, and scavenging system. After drawing the volatile anesthetic into the syringe, we were able to drop the anesthetic onto the vaporizing medium(gauze or cotton) manually or with an infusion pump. Highly concentrated anesthetic vapor diffuses out of the vaporizing chamber through the nose cone, which is punched more largely and closely to the center than in the margin to adequately diffuse the anesthetic vapor and to minimize excessive diffusion. Diffused gas is exhausted through the scavenging system to prevent pollution of the laboratory environment. Anesthesia depth can be controlled by adjusting the infusion rate and the position of the nose in the nose cone.
This apparatus males it possible for even non-skillful researchers to easily anesthetize small laboratory animals and to prevent pollution of the laboratory environment. With this apparatus, many volatile anesthetics can be used without selecting a specific vaporizer according to the research. It also reduces the cost for anesthesia equipment.
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